ROR1, GST-tag Recombinant

Catalog #
40396
$410 *
Size: 10 µg
Qty
*US Pricing only. For international pricing, please contact your local distributor.
Purchase
Description

Recombinant human ROR1 (GenBank Accession No. NM_005012), a.a. 429-end, with N-terminal GST-tag, MW 82 kDa, expressed in Sf9 insect cells via a baculovirus expression system.

Synonyms
dJ537F10.1; NTRKR1, neurotrophic tyrosine kinase, receptor-related 1, ROR, ROR-1
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
Sf9 insect cells
Purity

≥90%

Format
Aqueous buffer solution
Formulation
50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, and 25% glycerol.
MW
82 kDa
Amino Acids
429–end
Specific Activity
0.2 pmol/min/µg
Genbank #
NM_005012
UniProt #
Q01973
Tag(s)
N-terminal GST-tag
Background
ROR1 is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors that play a role in the control of most basic cellular processes including cell proliferation, differentiation, migration and metabolism (1). Many human breast cancers express the ROR1 protein and high-level expression of ROR1 in breast adenocarcinoma is associated with aggressive disease. Silencing expression of ROR1 in human breast cancer cell lines found to express this protein impaired their growth in vitro and also in immune-deficient mice (2).
References
1. Afzal, A. R. et.al. Hum. Mutat. 22: 1-11, 2003.
2. Zhang, S. et al. PLoS One. 2012;7(3):e31127.
3. Channavajhala, P., et al., J. Biol. Chem. 2003,278:47089-47097.
4. Rodriguez, C., et al., Cell Signal 2006,18(9):1376-1385.