Rolipram

Catalog #
27005
$160 *
Size: 10 mg
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Description

Rolipram is a selective, cell permeable inhibitor of cAMP-specific phosphodiesterase 4 (PDE4). PDE4 enzymes inactivate cyclic AMP (cAMP) via hydrolysis to 5'-AMP. Rolipram has two enantiomeric forms, R(-) and S(+). This product is the racemic mixture of the two enantiomers.

Product Info
Storage and Usage
Citations
Purity

≥95% by HPLC.

Format
White solid.
Formula
C16H21NO3
MW
275.34 Da
Solubility

insoluble in H2O; ≥13 mg/mL in DMSO; ≥24.65 mg/mL in EtOH with ultrasonic

Biological Activity

Rolipram inhibited PDE4 with IC50=1µM using the BPS Bioscience PDE4A Assay Kit (Cat. # 60340).

CAS Registry #
61413-54-5
References

1. Parker, C.A., et al., Synapse 55: 270 -279 (2005)
2. Barnard, J.W., et al., J. Appl. Physiol. 77: 774 – 781 (1994)
3. DeMarch, Z., et al., Neurobiol. Dis. 30: 375 – 387 (2008)