Rocilinostat (ACY-1215)

Catalog #

27644-1

$145 *

Size: 5 mg

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Bulk/Custom

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Description

Rocilinostat, also known as ACY-1215, is a selective HDAC6 inhibitor with IC50 of 5 nM. It is over 10-fold more selective for HDAC6 than HDAC1, 2, 3 (class I HDACs) with slight activity against HDAC8, and minimal activity against HDAC4, 5, 7, 9, 11, SIRT1, and SIRT2.

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Synonyms

Rocilinostat; ACY-1215; N-[7-(hydroxyamino)-7-oxoheptyl]-2-(N-phenylanilino)pyrimidine-5-carboxamide

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Product Data Gallery

Product Info

Storage and Usage

Citations

Purity

≥99% by HPLC

Target(s)

HDAC6

Formula

C₂₄H₂₇N₅O₃

433.5 Da

Solubility

Soluble in DMSO

CAS Registry #

1316214-52-4

References

1. Mithraprabhu S, et al. Br J Haematol. 2013 Aug;162(4):559-62. doi: 10.1111/bjh.12388.
2. Santo L, et al. Blood. 2012 Mar 15;119(11):2579-89.

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Rocilinostat (ACY-1215)

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