RbAp48, His-tag Recombinant
Catalog #
50297
$450
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Description
Human RbAp48 (GenBank Accession No. NM_005610), a.a. 2-end with N-terminal His-tag, MW= 48 kDa, expressed in a baculovirus expression system.
This product has been cited 2 times.
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Synonyms
RBAP48, Retinoblastoma Binding Protein 4, NURF55, Chromatin Assembly Factor 1 Subunit C, CAF1 p48, RBBP-4, Retinoblastoma-Binding Protein P48
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Product Info
Storage and Usage
Citations2
Species
Human
Host Species/Expression System
Sf9 insect cells
Purity
≥46%
Format
Aqueous buffer solution
Formulation
40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 3 mM DTT, 20% glycerol, and 200 mM imidazole
MW
48 kDa
Amino Acids
2–end
Genbank #
NM_005610
UniProt #
Q09028
Background
RbAp48 is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; the NURF (nucleosome remodeling factor) complex; and the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes.
References
1. Varambally, S. et al. Science 322 (5908), 1695-1699 (2008).
2. Rakotobe, D. et al., Virol. J. 5, 32 (2008).
2. Rakotobe, D. et al., Virol. J. 5, 32 (2008).