(R) - MG132

Catalog #: 27226
Size: 1 mg
$115
MW: 475.6 Da
CAS Registry #: 1211877-36-9
Formula: C26H41N3O5
Description:
(R)-MG132 is a potent, cell permeable and reversible inhibitor of proteasomes. It can inhibit proteasome activity in lysates of J558L multiple myeloma cells and EMT6 breast cancer cells. In comparison to (S)-MG132, the (R)-MG132 stereoisomer is a more effective inhibitor of chymotrypsin-like (ChTL), trypsin-like (TL), and peptidylglutamyl peptide hydrolyzing proteasome (PGPH) activities.
Synonym(s):
MG132
Purity:

≥98% by HPLC

Biological Activity:
(R)-MG132 inhibits ChTL, TL and PGPH with IC50 values of 0.22 µM, 34.4 µM, and 2.95 µM, respectively.
Solubility:
Soluble in ethanol, DMSO and DMF, purged with an inert gas. Solubility in these solvents is approximately 25 mg/ml
Format:
A crystalline solid.
Storage / Stability:
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s):
1. Lee, D.H., et al., Trends Cell Biol. 1998;8:397-403
2. Elliot, P.J., et al., J. Mol. Med. 2003;81:235-245
3. Mroczkiewicz, M., et al., J. Med. Chem. 2010;53:1509-1518.
Scientific Category:
Ubiquitin
Product Type:
Inhibitor
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Product Datasheets

27226_Lot150902.pdf