PTPσ (PTPRS), GST-tag

Catalog #: 30045
Size: 20 µg
$375
Species: Human
Host Species: E. coli
MW: 98 kDa
Genbank #: BC104812
Tag(s): N-terminal GST-tag
a.a: 883–end
Background:
PTPRS is a member of a subfamily of receptor type PTPases that is characterized by the presence of an extracellular cell adhesion molecule-like motif and 2 intracellular phosphatase domains. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis.
Description:
Human PTPRS (GenBank Accession No. BC104812), a.a. 883-end, with N-terminal GST-tag, MW= 98 kDa, expressed in an E. coli expression system.
Synonym(s):
PTPsigma, PTPRS, protein tyrosine phosphatase sigma, PTPσ
Specific Activity:
347 pmol/min/µg
Assay Conditions:
20 mM HEPES, pH 7.2, 2 mM EDTA, 1 mM DTT, 25 mM pNPP. Assay was done at room temperature for 16 minutes, and monitored continuously at Abs405 nM. ε pNPP = 18,000 M-1cm-1.
Formulation:
25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 20% glycerol, and 3 mM DTT.
Format:
Aqueous buffer solution
Storage / Stability:

>12 months at -80°C.

Application(s):
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Reference(s):
1. Forrest, A.R. et al., Genome Biol. 2006;7(1):R5.
2. Muise, A. and Rotin, D. Expert Rev Mol. Diagn. 2008 Jul;8(4):465-77.
Warning(s):
Avoid freeze/thaw cycles
Scientific Category:
PTP/Receptor
Product Type:
Recombinant Protein
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Product Datasheets

30045_Lot131002-G2.pdf