PS-341 (MG-341)
Catalog #
27715-1
$530
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Description
PS-341 (Pyz-Phe-boroLeu) is the active ingredient in Bortezomib. PS-341 is a reversible, cell permeable, potent, and selective proteasome inhibitor (Ki=0.6 nM). It binds the catalytic site of the 26S proteasome with high affinity and specificity. Inhibits proliferation of a number of tumor cell lines (IC50=7 nM). Inhibits TNF synthesis and FGF-induced angiogenesis.
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Synonyms
Pyz–Phe–boroLeu, N–(2–pyrazine)carbonyl–L–phenylalanyl–L–leucyl boronic acid
Product Info
Storage and Usage
Citations
Purity
>98% by HPLC.
Format
White powder
Formula
C19H25BN4O4
MW
384.2 Da
Solubility
Soluble in DMSO
CAS Registry #
179324-69-7
References
1. Yi-He Ling et all. PS-341, a Novel Proteasome Inhibitor, Induces Bcl-2 Phosphorylation and Cleavage in Association with G2-M Phase Arrest and Apoptosis. Mol Cancer Ther. 2002; 1:841-849.
2. Adams J. Development of the Proteasome Inhibitor PS-341. The Oncologist 2002; 7:9-16.
. Dudek SA et al. The clinically approved proteasome inhibitor PS-341 efficiently blocks influenza A virus and vesicular stomatitis virus propagation by establishing an antiviral state. J Virol. 2010 Sep;84:9439-51.
2. Adams J. Development of the Proteasome Inhibitor PS-341. The Oncologist 2002; 7:9-16.
. Dudek SA et al. The clinically approved proteasome inhibitor PS-341 efficiently blocks influenza A virus and vesicular stomatitis virus propagation by establishing an antiviral state. J Virol. 2010 Sep;84:9439-51.
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