Protease(s)

 

Protease is the name given to a class of enzymes that catalyze protein catabolism by hydrolysis of the peptide bonds linking amino acids together. Proteases have evolved to perform these reactions by numerous different mechanisms and are found in animals, plants, bacteria, archaea, and viruses, highlighting the important role that they play in all forms of life on Earth. Proteases are involved in protein processing, regulation of protein function, apoptosis, viral pathogenesis, digestion, photosynthesis, and numerous other vital processes.

More recently, various industries have begun to take advantage of proteases as an active ingredient in specific products or as a research tool. For example, laundry detergents contain proteases to help break down stains; proteases are often added to bread during the baking process to help soften the final product; and the biotech industry takes advantage of highly specific proteases, such as TEV protease and thrombin, to cleave fusion proteins.

Proteases also offer a valuable target in many therapeutic settings, including Alzheimer’s, cancer, and viral infection. In fact, one of the most widely-used classes of anti-viral therapeutics is protease inhibitors, which are used to treat both HIV and HCV infections.

BPS offers a wide selection of purified proteases, assay kits, fluorogenic substrates, and inhibitors/activators to reach all your research needs. In addition, we also offer protease screening and profiling services if you prefer to take advantage of our screening experience and expertise in this area.

References:

1. Overall, C.M. & Kleifeld, O., Nat. Rev. Canc. 2006; 6: 227-239.
2. Turk, B., Nat. Rev. Drug Disc. 2006; 5: 785-799.
3. Anderson, J. et al., Handbook of Experimental Pharmacology. 2009; 189: 85-110.

 

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Catalog#SizeProduct NamePrice
70000 50 µg Caspase7, His-tag
$435
80114 50 µg Caspase8, His-tag
$435
80115 50 µg Caspase9, His-tag
$355
80001 10 µg Cathepsin B, His-tag
$375
80003 50 µg Cathepsin F, His-tag
$365
80005 10 µg Cathepsin L, His-tag
$365
80008 10 µg Cathepsin S, His-tag
$365
80009 10 µg Cathepsin V, His-tag
$375
27052 2 mg Danoprevir
$195
27703-2 25 mg DBeQ
$270
80300 20 ml DPP Assay Buffer
$35
80030 10 µg DPP3, GST-tag
$425
80040 10 µg DPP4, His-tag
$420
80070 10 µg DPP7, His-tag
$415
80080 10 µg DPP8, GST-tag
$435
80090 10 µg DPP9, GST-Tag
$425
80100 10 µg FAP, His-tag
$425
80350 100 µl Fluorogenic Cathepsin F Substrate
$200
80349 100 µl Fluorogenic Cathepsin V Substrate
$200
80305 100 µl Fluorogenic DPP substrate1
$200
80332 100 µl Fluorogenic DPP substrate2
$200
27750-2 10 mg Ganetespib (STA-9090)
$270
27750-1 5 mg Ganetespib (STA-9090)
$220
80102 20 µg HCV1a (D168E), FLAG-His-tags
$405
80103 20 µg HCV1a (D168V), FLAG-His-tags
$405

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