Protease(s)

 

Protease is the name given to a class of enzymes that catalyze protein catabolism by hydrolysis of the peptide bonds linking amino acids together. Proteases have evolved to perform these reactions by numerous different mechanisms and are found in animals, plants, bacteria, archaea, and viruses, highlighting the important role that they play in all forms of life on Earth. Proteases are involved in protein processing, regulation of protein function, apoptosis, viral pathogenesis, digestion, photosynthesis, and numerous other vital processes.

More recently, various industries have begun to take advantage of proteases as an active ingredient in specific products or as a research tool. For example, laundry detergents contain proteases to help break down stains; proteases are often added to bread during the baking process to help soften the final product; and the biotech industry takes advantage of highly specific proteases, such as TEV protease and thrombin, to cleave fusion proteins.

Proteases also offer a valuable target in many therapeutic settings, including Alzheimer’s, cancer, and viral infection. In fact, one of the most widely-used classes of anti-viral therapeutics is protease inhibitors, which are used to treat both HIV and HCV infections.

BPS offers a wide selection of purified proteases, assay kits, fluorogenic substrates, and inhibitors/activators to reach all your research needs. In addition, we also offer protease screening and profiling services if you prefer to take advantage of our screening experience and expertise in this area.

References:

1. Overall, C.M. & Kleifeld, O., Nat. Rev. Canc. 2006; 6: 227-239.
2. Turk, B., Nat. Rev. Drug Disc. 2006; 5: 785-799.
3. Anderson, J. et al., Handbook of Experimental Pharmacology. 2009; 189: 85-110.

 

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Catalog#SizeProduct NamePrice
79588 96 reactions Cathepsin S Inhibitor Screening Assay Kit
$440
80008 10 µg Cathepsin S, His-tag
$375
79589 96 reactions Cathepsin V Inhibitor Screening Assay Kit
$440
80009 10 µg Cathepsin V, His-tag
$385
27052 2 mg Danoprevir
$200
27703-2 25 mg DBeQ
$280
80300 20 ml DPP Assay Buffer
$40
80203 96 reactions DPP3 Assay Kit
$590
80030 10 µg DPP3, GST-tag
$440
80204 96 reactions DPP4 Assay Kit
$440
80040 10 µg DPP4, His-tag
$435
80207 96 reactions DPP7 Assay Kit
$490
80070 10 µg DPP7, His-tag
$425
80208 96 reactions DPP8 Assay Kit
$490
80080 10 µg DPP8, GST-tag
$450
80209 96 reactions DPP9 Assay Kit
$590
80090 10 µg DPP9, GST-Tag
$440
80210 96 reactions FAP Assay Kit
$980
80100 25 µg FAP, His-tag
$440
100226 25 µg FAP, His-Tag (Mouse)
$435
80350 100 µl Fluorogenic Cathepsin F Substrate
$205
80349 10 µl Fluorogenic Cathepsin Substrate 1
$205
80305 100 µl Fluorogenic DPP substrate1
$205
80332 100 µl Fluorogenic DPP substrate2
$205
27750-2 10 mg Ganetespib (STA-9090)
$280

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