Proteases

Sortases catalize a transpeptidation reaction, where the enzyme cleaves the amide bond between the threonine and glycine of the sortase recognition sequence (LPXTG for S. aureus Sortase A), generating a thioacyl intermediate. Subsequently,  this intermediate is resolved by the N-terminus of an oligoglycine nucleophile,  creating a new peptide bond that links the substrate to the incoming nucleophile.


 

 
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