DPP8, GST-tag

Catalog #: 80080
Size: 10 µg
$435
Species: Human
Host Species: Sf9 insect cells
MW: 129.3 kDa
Genbank #: NM_197960
Tag(s): N-terminal GST-tag
a.a: full length
Background:
Dipeptidyl peptidase-8 (DPP8) is a ubiquitously expressed serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. DPP8 shares homology and substrate recognition patterns with DPP4 and like DPP4, is thought to play a role in T-cell activation and immune function.
Description:

Human DPP8 (Dipeptidylpeptidase 8), GenBank Accession No. NM_197960, full length with N-terminal GST-tag, MW=129.3 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

UniProt
Q6V1X1
Synonym(s):
Dipeptidylpeptidase 8, MSTP141, DPP8 Protein, DPP
Specific Activity:
≥ 560 pmol/min/µg
Assay Conditions:
50 mM Tris (pH 7.4), 0.1% BSA, 10 µM Ala-Pro-AMC, 10 min. at room temperature.
Formulation:
45 mM Tris-HCl, pH 8.0, 124 mM NaCl, 2.4 mM KCl, 18 mM Glutathione, 10% glycerol, and 3 mM DTT.
Format:
Aqueous buffer solution
Storage / Stability:

>6 months at -80°C.

Application(s):
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Reference(s):

1. Lee, H.J. et al., J. Biol. Chem. 281 (50), 38653-38662 (2006).
2. Yu, D.M. et al., FEBS J. 273 (11), 2447-2460 (2006).

Application Reference(s): 
1. ZY15557, a novel, long acting inhibitor of dipeptidyl peptidase-4, for the treatment of Type 2 diabetes mellitus (2017)

Warning(s):
Avoid freeze/thaw cycles
Scientific Category:
Protease
Product Type:
Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.

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Product Datasheets

80080_Lot120827-GC.pdf