PrCP, His-tag Recombinant
Catalog #
80380
$450
*
●
●
Purchase
Description
Human recombinant Lysosomal Pro-X carboxypeptidase, also known as angiotensinase C (GenBank Accession #NM_005040), a.a. 31-496 with C-terminal His-tag, MW=53 kDa, expressed in HEK293 cells.
●
Synonyms
Proline Carboxypeptidase, Angiotensinase C, PCP, Lysosomal Pro-X carboxypeptidase
●
Product Data Gallery
10% SDS-PAGE Coomassie Staining
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
FreeStyle 293-F cells
Purity
≥15%
Format
Aqueous buffer solution
Formulation
40 mM Tris pH 8.0, 110 mM NaCl, 2.2 mM KCl, 20% glycerol, 3 mM DTT, 200 mM imidazole
MW
53 kDa
Amino Acids
31–496
Genbank #
NM_005040
UniProt #
P42785
Background
PrCP is a lysosomal prolylcarboxypeptidase that cleaves C-terminal amino acids linked to proline. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. PrCPs role in angiotension II cleavage, which regulates blood pressure and electrolyte balance, suggests that PrCP may be involved in hypertension.
References
1. Tan, F., et al. 1993. J Biol Chem 268 (22): 16631–8.
2. Yang, H.Y., et al. 1968. Nature 218 (5148): 1224–6.
3. Wang, L., et al. 2006. Am. J. Obstet. Gynecol. 195 (1): 162–71.
2. Yang, H.Y., et al. 1968. Nature 218 (5148): 1224–6.
3. Wang, L., et al. 2006. Am. J. Obstet. Gynecol. 195 (1): 162–71.
Powered by Bioz
6405 Mira Mesa Blvd. Suite 100
San Diego, CA 92121
858-202-1401
San Diego, CA 92121
858-202-1401
Products are for Research Use Only
COMPANY
Copyright © 2024
BPS Bioscience, Inc.
All rights reserved.
Diagrams on this website are created with BioRender.com.