PR-619

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Catalog #
27714
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Description

PR-619 is a non-selective, reversible inhibitor of deubiquitinases/deubiquitylases (DUBs) and ubiquitin-like isopeptidases. PR-619 inhibits many deubiquitinating enzymes in the 5-20 μM range. Additionally, PR-619 is cell permeable and treatment of cells results in the accumulation of both ubiquitin and sumo-conjugated proteins.

Synonyms
Thiocyanic acid, C,C′–(2,6–diamino–3,5–pyridinediyl) ester, 27714-1, 27714-2
Product Info
Storage and Usage
Citations
Purity
≥95% by HPLC.
Format
Dry powder
Formula
C7H5N5S2
MW
223.3 Da
Solubility
Soluble in DMSO (10 mM)
CAS Registry #
2645-32-1