JW 55

Catalog #

27633-1

$185 *

Size: 10 mg

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Description

Cell-permeable, reversible tankyrase 1 (PARP5a) and tankyrase 2 (PARP5b) inhibitor. Also inhibits the β-catenin mediated canonical Wnt pathway

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Synonyms

N-[4-[[4-(4-methoxyphenyl)oxan-4-yl]methylcarbamoyl]phenyl]furan-2-carboxamide

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Product Info

Storage and Usage

Citations

Purity

≥98% by HPLC

Target(s)

TNKS1, TNKS2

Formula

C₂₅H₂₆N₂O₅

434.5 Da

Solubility

Soluble in DMSO

Biological Activity

JW55 decreased auto-PARsylation of TNKS1 and TNKS2 in vitro with IC50 values of 1.9 µM and 830 nM respectively.

CAS Registry #

664993-53-7

Background

Inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). Activity results in stabilization of Axin2 and increased degradation of β-catenin; inhibits the β-catenin signaling pathway. Also shown to decrease canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines; reduces cell cycle progression and proliferation in SW480 cells in vitro.

References

Waaler, J. et al. (2012). Cancer Res. 72 2822-32.

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JW 55

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