AZD2461
Catalog #
27606-1
$175
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Description
AZD2461 is a novel PARP inhibitor with low affinity for than Olaparib. AZD2641 is currently in Phase I clinical studies to treat solid tumors.
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Synonyms
4-[[4-fluoro-3-(4-methoxypiperidine-1-carbonyl)phenyl]methyl]-2H-phthalazin-1-one
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Product Data Gallery
Product Info
Storage and Usage
Citations
Purity
≥98% by HPLC
Formula
C22H22FN3O3
MW
395.4 Da
Solubility
Soluble in DMSO
Biological Activity
PARP inhibitor (IC50 = 5 nM)
CAS Registry #
1174043-16-3
Background
Unlike treatment with AZD 2281 (Olaparib, Axon 1464), AZD 2461 succesfully circumvents drug resistance of Pgp-proficient tumors, and inactivation of p53-binding protein 1 (53BP1) as a causal factor in PARPi resistance.
References
J.E. Jaspers et al. Cancer Discov. 2013, 3, 68-81.
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