PLK3 Polo Box Domain, MBP-tag, His-tag Recombinant
Catalog #
50302
$415
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Description
Human N-terminal MBP tagged Plk3 polo box domain (GenBank Accession No.NM_004073/NP_004064), a.a. 335-646 with C-terminal His-tag, MW=80.5 kDa, expressed in an E. coli expression system.
This product has been cited 3 times.
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Synonyms
CNK, FNK, PRK, polo-like kinase 3
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Product Data Gallery
4-20% SDS-PAGE Coomassie Staining
Product Info
Storage and Usage
Citations3
Species
Human
Host Species/Expression System
E. coli
Purity
≥90%
Format
Aqueous buffer solution
Formulation
45 mM Tris-HCl, pH 8.0, 124 mM NaCl, 2.4 mM KCl, 10% glycerol, 225 mM imidazole, and 3 mM DTT.
MW
80.5 kDa
Amino Acids
335–646
Genbank #
NM_004073
UniProt #
Q9H4B4
Background
PLK3 or Polo-like kinase 3 is a cytokine-inducible kinase that is a member of the Polo family of serine/threonine protein kinases. PLK3 contains both a catalytic domain and a putative regulatory domain and plays an important role in the regulation of cell cycle progression and tumorigenesis. PLK3 is closely associated with centrosomes in several human cell lines and its localization is dependent on the integrity of microtubules. Hence, PLK3 is also involved in regulating microtubule dynamics and centrosomal function.
References
1. Li, Z., et al., J. Biol. Chem. 280 (17), 16843-16850 (2005).
2.Xie,S., et al., Oncogene 23 (21), 3822-3829 (2004).
2.Xie,S., et al., Oncogene 23 (21), 3822-3829 (2004).
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