PLK1 Polo Box Domain, GST-tag

Catalog #: 50301
Size: 100 µg
$405
Species: Human
Host Species: E. coli
MW: 53 kDa
Genbank #: NM_005030
Tag(s): N-terminal GST-tag
a.a: 367–end
Background:
PLK1 is a member of the Polo-Like Kinase family that localize to centrosomes or spindle pole bodies and undergo dramatic subcellular relocation during the cell cycle. Deregulated activities of PLKs often result in abnormalities in centrosome duplication, maturation, and/or microtubule dynamics. PLKs also regulate the function of the Golgi complex. Deregulated expression of human PLK1 is strongly correlated with the development of many types of malignancies, and ectopic expression of PLK1 dominant negative protein leads to rapid cell death.
Description:
Human Plk1 polo box domain (GenBank Accession No. NM_005030), a.a. 367-end with N-terminal GST-tag, MW=53 kDa, expressed in an E. coli expression system.
UniProt
P53350
Synonym(s):
STPK13, polo-like kinase 1
Formulation:
40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 3 mM DTT, 20% glycerol, and 16 mM glutathione
Format:
Aqueous buffer solution
Storage / Stability:

>6 months at -80°C.

Application(s):
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Warning(s):
Avoid freeze/thaw cycles
Scientific Category:
Kinase/Serine-Threonine
Product Type:
Recombinant Protein
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