PJ34

Catalog #

27041

$125 *

Size: 1 mg

Qty

Bulk/Custom

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Description

A cell-permeable, water-soluble, potent inhibitor of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM). Shown to be about 10,000 times more potent than the prototypical PARP inhibitor, 3-Aminobenzamide (Cat. No. 165350; EC50 = 200 µM). Does not act as an antioxidant at higher concentrations (1 µM to 10 mM). Exhibits neuroprotection in in vivo and in vitro models of stroke.

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Synonyms

N-(5,6-Dihydro-6-oxo-2-phenanthridinyl)-2-acetamide hydrochloride

Product Info

Storage and Usage

Citations

Purity

≥98%

Format

White to light brown powder.

Formula

C₁₇H₁₇N₃O₂ • HCl

331.8 Da

Solubility

Soluble to 100 mM in water and to 100 mM in DMSO

CAS Registry #

344458-15-7

References

Huang, S.H., et al. Oncol Rep. 2008 Sep;20(3):567-72.

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