Milrinone
Catalog #
27216
$195
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Description
Milrinone, also known as WIN 47203 and Primacor®, is an inhibitor of PDE3. It is less effective against other PDE isoforms. Milrinone has positive inotropic and vasodilatory effects in vivo.
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Product Info
Storage and Usage
Citations
Purity
≥98% by HPLC
Format
A crystalline solid.
Formula
C12H9N3O
MW
211.2 Da
Solubility
Soluble in DMSO and DMF, purged with an inert gas. Solubility in DMSO and DMF is ~0.3 mg/ml.
Biological Activity
Milrinone inhibits PDE3A and PDE3B with IC50 values of 0.45 µM and 1.0
µM, respectively.
CAS Registry #
78415-72-2
References
1. Sudo, T., et al., Biochem Pharmacol. 2000;59:347-56.
2. Lakshminrusimha, S., et al., Pediatr. Crit. Care Med. 2009;10(1):106-12.
3. Simkova, V., et al., Crit. Care. 2007;11(3):139.
4. Maskin, C.S., et al., Circ. J. 1983;67:1065-70.
2. Lakshminrusimha, S., et al., Pediatr. Crit. Care Med. 2009;10(1):106-12.
3. Simkova, V., et al., Crit. Care. 2007;11(3):139.
4. Maskin, C.S., et al., Circ. J. 1983;67:1065-70.