Icariin

Catalog #

27217

$150 *

Size: 1 g

Qty

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Description

Icariin is a PDE5 inhibitor. It is the active component of the Chinese medicinal plant E. brevicornum. It can induce differentiation of cardiomyocytes and upregulates the expression of cardiac genes. Icariin increase the proliferation and differentiation of cultured human osteoblasts, which appears to be mediated in part by upregulating bone morphogenetic protein 2 mRNA.

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Product Info

Storage and Usage

Citations

Purity

≥97% by HPLC

Format

A crystalline solid.

Formula

C₃₃H₄₀O₁₅

676.6 Da

Solubility

Soluble in DMSO and DMF, purged with an inert gas. Solubility in DMSO and DMF is ~20 mg/ml. For maximum solubility, dissolve in DMSO and then dilute with the aqueous buffer of choice.

Biological Activity

Icariin inhibits human recombinant PDE5 with an IC50 value of 5.9 µM.

CAS Registry #

489-32-7

References

1. Dell’Agli, M, et al., J. Nat. Prod. 2008;71(9):1513-1517.
2. Chen, Y., et al., Pharm Res. 2008;25(9):2190-2199.
3. Ding, L., et al., Acta Pharmacol Sin. 2007;28(10):1541-1549.
4. Yin, X., et al., Chin Med J. 2007;120(3):204-210.

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Icariin

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