CP 80633

Catalog #
27301
$310 *
Size: 10 mg
Qty
*US Pricing only. For international pricing, please contact your local distributor.
Purchase
Description

CP 80633 is a selective inhibitor of PDE4, which does not display significant isozyme selectivity. It also inhibits hydrolysis of cAMP in isolated monocytes, eosinophils, human peripheral blood and T-cells. It has been shown to exhibit anti-inflammatory and bronchodilatory activity in vivo.

Product Info
Storage and Usage
Citations
Purity

≥95% by HPLC

Format
A crystalline solid.
Formula
C18H24N2O3
MW
316.4 Da
Solubility
Soluble in 100 mM DMSO or 100 mM Ethanol.
Biological Activity
CP-80633 inhibits PDE4 isozymes (human lung IC50 = 1.27 µM) in the absence of effects on PDE1, PDE2, PDE3 and PDE5 isozymes (IC50 > 100 µM).
CAS Registry #
135637-46-6
References
1. Turner, CR., et al., J. Pharmacol. Exp. Ther. 1996 Sept;278(3):1349-55.
2. Cohan, VL., et al., J. Pharmacol. Exp. Ther. 1996 Sept;278(3):1356-61.
3. Cheng, JB., et al., J. Pharmacol. Exp. Ther. 1997 Feb;280(2):621-6.