CP 80633
Catalog #
27301
$310
*
●
●
Purchase
Description
CP 80633 is a selective inhibitor of PDE4, which does not display significant isozyme selectivity. It also inhibits hydrolysis of cAMP in isolated monocytes, eosinophils, human peripheral blood and T-cells. It has been shown to exhibit anti-inflammatory and bronchodilatory activity in vivo.
●
Product Data Gallery
Product Info
Storage and Usage
Citations
Purity
≥95% by HPLC
Format
A crystalline solid.
Formula
C18H24N2O3
MW
316.4 Da
Solubility
Soluble in 100 mM DMSO or 100 mM Ethanol.
Biological Activity
CP-80633 inhibits PDE4 isozymes (human lung IC50 = 1.27 µM) in the absence of effects on PDE1, PDE2, PDE3 and PDE5 isozymes (IC50 > 100 µM).
CAS Registry #
135637-46-6
References
1. Turner, CR., et al., J. Pharmacol. Exp. Ther. 1996 Sept;278(3):1349-55.
2. Cohan, VL., et al., J. Pharmacol. Exp. Ther. 1996 Sept;278(3):1356-61.
3. Cheng, JB., et al., J. Pharmacol. Exp. Ther. 1997 Feb;280(2):621-6.
2. Cohan, VL., et al., J. Pharmacol. Exp. Ther. 1996 Sept;278(3):1356-61.
3. Cheng, JB., et al., J. Pharmacol. Exp. Ther. 1997 Feb;280(2):621-6.