Cilostazol

Catalog #

27743-2

$185 *

Size: 100 mg

Qty

Bulk/Custom

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Description

Cilostazol is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 µM and inhibitor of adenosine uptake.

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Synonyms

Pletal; OPC-13013

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Product Info

Storage and Usage

Citations

Format

white to off-white crystals

Target(s)

PDE3

Formula

C₂₀H₂₇N₅O₂

369.5 Da

Solubility

Soluble in DMSO (18 mg/ml).

CAS Registry #

73963-72-1

Background

Cilostazol (OPC-13013, Pletal) is a 2-oxo-quinoline derivative with antithrombotic, vasodilator, antimitogenic and cardiotonic properties. Cilostazol is used in the treatment of peripheral arterial disease and claudication (leg cramps). Cilostazol inhibits platelet aggregation and is a direct arterial vasodilator.

References

1. Cone J, et al. J Cardiovasc Pharmacol, 1999, 34(4), 497-504.
2. Liu Y, et al. Cardiovasc Drug Rev, 2001, 19(4), 369-386.

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Cilostazol

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