BAY-60-7550

Catalog #

27215

$385 *

Size: 5 mg

Qty

Bulk/Custom

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Description

BAY-60-7550 is a potent inhibitor of PDE2. It is more selective for PDE2 than PDE1 by 50-fold. Similarly, it is 100-fold more selective for PDE4B, PDE5B, PDE7B, PDE8A, PDE9A, PDE10A, and PDE11A.

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Product Info

Storage and Usage

Citations

Purity

≥95% by HPLC

Format

A crystalline solid.

Formula

C₂₇H₃₂N₄O₄

476.6 Da

Solubility

Soluble in ethanol, DMSO and DMF, purged with an inert gas. Solubility in ethanol, DMSO and DMF is ~10 mg/ml.

Biological Activity

BAY-60-7550 inhibits PDE2 with an IC50 of 2.0 nM in bovine, and 4.7 nM in humans.

CAS Registry #

439083-90-6

References

1. Boess, F.G., et al., Neuropharmacology. 2004; 47: 1081-1092.
2. Masood, A., et al., J. Pharmacol. Exp. Ther. 2008; 326(2): 369-379.
3. Rutten, K., et al., Neuropsychopharmacology. 2009; 34: 1914-1925.

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