PD-1 (E136A), Fc fusion, Biotin-labeled (Human) HiP™ Recombinant

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Catalog #
71247
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Description

Recombinant human PD-1 (Programmed Cell Death 1),  encompassing amino acids 25-167.  The C-terminus is fused with the Fc fragment of a human IgG1 followed by an Avi-Tag™. This protein contains mutation of interest (E136A). The recombinant protein was enzymatically biotinylated using the Avi-Tag™ and affinity purified.  HiP™ indicates a high purity protein (≥90% pure) and less than 10% aggregation as measured by gel filtration.

Synonyms
Programmed cell death 1, PDCD1, PD-1, PD1, SLEB2, CD279, HPD-L
Product Info
Storage and Usage
Citations
Species
Human
Construct
PD-1 (E136A) (25-167-Fc(IgG1)-Avi)-(Biotin)
Mutation
E136A
Host Species/Expression System
HEK293
Purity

≥90%

Format

Aqueous buffer solution

Formulation

8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol

MW
45 kDa + glycans
Amino Acids
25-167
Glycosylation
This protein runs at a higher MW by SDS-PAGE due to glycosylation.
Aggregation
<10%
Genbank #
NM_005018
UniProt #
Q15116
Tag(s)
C-terminal AviTag™
Label

This protein is enzymatically biotinylated using Avi-Tag™ technology. Biotinylation confirmed to be ≥90%.

For more information on enzymatic biotinylation, please see our Tech Note

References
1. Freeman, G.J., et al., J. Exp. Med. 2000 Oct 2;192(7):1027-34.
2. Dong, H., et al., Nat Med. 1999 Dec;5(12):1365-9.