PCGF6, GST-tag Recombinant

Catalog #

55016

$455 *

Size: 50 µg

Qty

Bulk/Custom

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Description

Human Polycomb group RING finger protein 6 (PCGF6), GenBank Accession No. NM_001011663, a.a. 2-350 (end), with N-terminal GST-tag, MW=65.7 kDa, expressed in a baculovirus expression system.

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Synonyms

Polycomb group RING finger protein 6, PCGF6, Mel18 And Bmi1-Like RING Finger Protein, MBLR, RNF134

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Product Data Gallery

4-20% SDS-PAGE Coomassie Staining

Product Info

Storage and Usage

Citations

Host Species/Expression System

Sf9 insect cells

Purity

≥86%

Format

Aqueous buffer solution

Formulation

40 mM Tris. pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, and 20% glycerol.

65.7 kDa

Amino Acids

2–350 (end)

Genbank #

NM_001011663.1

UniProt #

Q9BYE7

Tag(s)

N-terminal GST-tag

Background

Transcriptional repressor that modulates the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility.

References

1. Junco SE, et al.,Structure. 2013;
21(4):665-71.
2. Kajiume T, et al., Exp Hematol.
2012; 40(9):751-760.

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Datasheets/Protocols

55016_Lot130522-G.pdf

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PCGF6, GST-tag Recombinant

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