PAC-1

Catalog #
27043
$160 *
Size: 10 mg
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Description

Procaspase-activating compound; activates procaspase-3 to produce caspase-3 (EC50 = 0.22 µM). Also activates procaspase-7 in a less efficient manner (EC50 = 4.5 µM). Pro-apoptotic; induces apoptosis in both cancerous and non-cancerous cells dependent on procaspase-3 concentration (IC50 values are 0.003 - 1.41 and 5.02 - 9.98 µM respectively). PAC-1 had an IC50 value of 3 nM for induction of cell death, whereas in cells from adjacent normal tissue IC50 values of 3.2-8.5 µM were observed

Synonyms
4-(Phenylmethyl)-1-piperazineacetic­ acid [[2-hydroxy-3-(2-propenyl)phenyl]methylene]hydrazi­de
Product Info
Storage and Usage
Citations
Purity

≥99%

Format
A crystalline solid.
Formula
C23H28N4O2
MW
392.5 Da
Solubility
Soluble to 75 mM in 1eq. HCl and to 100 mM in DMSO
CAS Registry #
315183-21-2
References
1. Putt et al. (2006). Nat.Chem.Biol. 2 543. PMID: 16936720.
2. Peterson et al. (2009). J.Med.Chem. 52 5721. PMID: 19708658.