P22077

Catalog #

27712-2

$495 *

Size: 50 mg

Qty

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Description

P22077 is a cell permeable inhibitor of the ubiquitin-specific protease USP7 (IC50=8.6 µM), and the closely related deubiquitinase (DUB) USP47. P22077 showed weak or no inhibition (EC50 >50µM) towards a panel of 14 isopeptidases and other proteases. Treatment of cells with P22077 (20–40 µM) causes an accumulation of K48-linked ubiquitinated species, and down regulation of the USP7 targets HDM2 and claspin.

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Synonyms

Ethanone, 1–[5–[(2,4–difluorophenyl)thio]–4–nitro–2–thienyl]– USP-7, USP-47

Product Info

Storage and Usage

Citations

Purity

≥98% by HPLC.

Format

Light powder

Formula

C12H7F2NO3S2

315.3 Da

Solubility

Soluble in DMSO

CAS Registry #

1247819-59-5

References

1. Altun, M., et al. , Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. Chem Biol, 2011. 18(11): p. 1401-12.
2. Tian, X., et al., Characterization of selective ubiquitin and ubiquitin-like protease inhibitors using a fluorescence-based multiplex assay format. Assay Drug Dev Technol, 2011. 9(2): p. 165-73.

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