Wnt-C59

Catalog #
27780-1
$330 *
Size: 10 mg
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Description

Wnt-C59 is a very potent and highly selective Wnt signaling antagonist with an IC50 ~ 74 pM in the Wnt signaling reporter assay.

Synonyms
2-[4-(2-Methylpyridin-4-yl)phenyl]-N-[4-(pyridin-3-yl)phenyl]acetamide
Product Info
Storage and Usage
Citations
Target(s)
Porcupine
Formula
C25H21N3O
MW
379.5 Da
Solubility
Soluble in DMSO
CAS Registry #
1243243-89-1
Background
Wnt-C59 prevents palmitoylation of Wnt proteins by Porcupine (a membrane-bound O-acyltransferase), thereby blocking Wnt protein secretion and activity, similar to Wnt inhibitors IWP-2, IWP-3 and IWP-4. But Wnt-C59 is more potent and selective, and has better chemical/physical properties, and is more suitable for in vitro/in vivo studies.
References
Proffitt KD, et al. Cancer Res. 2013 Jan 15;73(2):502-7.