Novobiocin

Catalog #

27501

$200 *

Size: 250 µl

Qty

Bulk/Custom

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Description

Novobiocin is an aminocoumarin antibiotic that is produced by Streptomyces niveus. Along with other aminocoumarin antibiotics, novobiocin is a very potent inhibitor of bacterial DNA gyrase. It works by targeting the GyrB subunit of the enzyme involved in energy transduction.

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Product Info

Storage and Usage

Citations

Purity

≥93% by HPLC

Supplied As

400 µM solution in anhydrous DMSO

Format

A red aqueous solution

Formula

C₃₁H₃₅N₂NaO₁₁

634.6 Da

Biological Activity

Novobiocin has been shown to inhibit bacterial DNA gyrase supercoiling with an IC50 of 0.08 µM

CAS Registry #

1476-53-5 (Novobiocin, sodium salt)

References

1. Lamour V, et al., J Biol Chem. 2002 May 24;277(21):18947-53.
2. Alt, S., et al., J Antimicrob Chemother. 2011 Jun 11; doi:10.1093/jac/dkr247.

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