Catalog #: 27500
Size: 20 µl @ 10 µM
CAS Registry #: 1476-53-5 (Novobiocin, sodium salt)
Chemical Formula: C70H80N6O18S2
Molecular Weight: 1357.5
Description: Novobiocin is an aminocoumarin antibiotic that is produced by Streptomyces
niveus. Along with other aminocoumarin antibiotics, novobiocin is a very potent inhibitor of
bacterial DNA gyrase. It works by targeting the GyrB subunit of the enzyme involved in energy
transduction. Novo-TRX is Texas Red-labeled novobiocin, which can be used as a fluorescence
probe in assays for screening DNA gyrase inhibitors.
Appearance: A red aqueous solution
Formulation: Supplied as a 10 µM solution in anhydrous DMSO
Biological Activity: Novo-TRX has been shown to inhibit bacterial DNA gyrase activity with an
IC50 of 0.6 µM.
Storage/Stability: Store at or below -20°C.
Quality Control: The purity was determined by HPLC analysis.
1. Lamour V, et al., J Biol Chem. 2002 May 24;277(21):18947-53.
2. Glaser BT, et al., J Biomol Screen. 2011 Feb;16(2):230-8.
PRODUCT DATA SHEETS
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