Novo-TRX
Catalog #: 27500

Size: 20 µl @ 10 µM

Structure:

CAS Registry #: 1476-53-5 (Novobiocin, sodium salt)

Purity: ≥93.3%

Chemical Formula: C₇₀H₈₀N₆O₁₈S₂

Molecular Weight: 1357.5

Description: Novobiocin is an aminocoumarin antibiotic that is produced by Streptomyces
niveus. Along with other aminocoumarin antibiotics, novobiocin is a very potent inhibitor of
bacterial DNA gyrase. It works by targeting the GyrB subunit of the enzyme involved in energy
transduction. Novo-TRX is Texas Red-labeled novobiocin, which can be used as a fluorescence
probe in assays for screening DNA gyrase inhibitors.

Appearance: A red aqueous solution

Formulation: Supplied as a 10 µM solution in anhydrous DMSO

Biological Activity: Novo-TRX has been shown to inhibit bacterial DNA gyrase activity with an
IC50 of 0.6 µM.

Storage/Stability: Store at or below -20°C.

Quality Control: The purity was determined by HPLC analysis.

Reference(s):
1. Lamour V, et al., J Biol Chem. 2002 May 24;277(21):18947-53.
2. Glaser BT, et al., J Biomol Screen. 2011 Feb;16(2):230-8.

PRODUCT DATA SHEETS
Lot 120723

Data shown is lot-specific. For specific information on other lots, please contact us.