Nutlin-3
Catalog #
27711
$250
*
●
●
Purchase
Description
Cis-imidazoline analog that inhibits the interaction between p53 and its negative regulator MDM2 (IC50 = 0.09 μM). It induces the expression of p53-regulated genes and exhibits potent antiproliferative activity in cells with functional p53, but not in cells with mutated p53. Nutlin-3 also inhibits the growth of human tumor xenografts in nude mice by 90% at a dose of 200 mg/kg.
●
Synonyms
(±)–4–[4,5–Bis(4–chlorophenyl)–2–(2–isopropoxy–4–methoxy–phenyl)–4,5–dihydro–imidazole–1–carbonyl]–piperazin–2–one
Product Info
Storage and Usage
Citations
Purity
>98% by TLC.
Format
White crystalline solid
Formula
C30H30Cl2N4O4
MW
581.5 Da
Solubility
Soluble in DMSO (50 mg/ml)
CAS Registry #
548472-68-0
References
1. Vassilev L.T. et al. In vivo activation of the p53 pathway by small -molecule antagonists of MDM2. Science 2004. 303(5659):844.
Powered by Bioz
6405 Mira Mesa Blvd. Suite 100
San Diego, CA 92121
858-202-1401
San Diego, CA 92121
858-202-1401
Products are for Research Use Only
COMPANY
Copyright © 2024
BPS Bioscience, Inc.
All rights reserved.
Diagrams on this website are created with BioRender.com.