Human Neurotrophin-4 Recombinant

Catalog #

90226-A

$130 *

Size: 2 µg

Qty

Bulk/Custom

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Description

Recombinant NT-4 is a disulfide-linked homodimer protein consisting of two 131 amino acid residues, and migrates as an approximately 29 kDa protein under non-reducing and as 14 kDa under reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Neurotrophin-4 mature chain was expressed in E. coli.

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Synonyms

NT4, Neurotrophin 4, Neurotrophin 5, NT-4, NTF5, NTF-5, NTF4, NTF-4, NT5

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

E. coli

Purity

≥97% by SDS-PAGE and HPLC

Format

lyophilized protein

Formulation

Lyophilized from a 0.2 µm filtered PBS solution, pH 7.5.

14 kDa

Endotoxin Level

<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.

Amino Acids

81–210

Biological Activity

The ED₅₀ was determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cell cultures, and was found to be in a range of 10-50 ng/ml.

Genbank #

P34130

UniProt #

P34130

Background

Neurotrophins are well-known retrograde signaling molecules that regulate differentiation and cell survival in many central and peripheral neurons. Neurotrophin-4 (NT-4) is the most recently discovered neurotrophic factor in mammals and, functionally, the least well understood. Little is known about the role of NT-4 in supporting the survival of identified classes of sensory neurons. Mice lacking NT4 (NT4/) exhibit a loss of ~50% of the neurons in the nodose-petrosal and geniculate ganglia but no apparent loss of neurons in the dorsal root ganglia.

References

1. J. Biol. Chem., Feb 2008, 283: 3385 - 3391.
2. J. Pharmacol. Exp. Ther., Nov 2005, 315: 796 - 804.

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Human Neurotrophin-4 Recombinant

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