The Wnt /β-catenin signaling pathway plays key roles in stem cell biology, aging, cancer development, cardiac and neural development, and embryogenesis. Inhibitors of Wnt signaling have therapeutic potential for cancer and other disorders and diseases.
PDE1B plays a key role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Both cAMP and cGMP are hydrolyzed by PDE1B into nucleoside 5′-monophosphate, yet PDE1B prefers cGMP at low substrate levels.
Ubiquitination controls the degradation, stability, function, structure, and intracellular localization of a wide variety of proteins.