Human Neuregulin 1 beta

Catalog #: 90224-B
Size: 50 µg
Species: Human
Host Species: E. coli
MW: 7 kDa
Genbank #: Q02297
a.a: 177–237
Neuregulins (NDF, heregulin, GGF ARIA, or SMDF) are EGF-like growth and differentiation factors that signal through tyrosine kinase receptors of the ErbB family. The ErbB2 and ErbB4 receptors cooperate in transmission of neuregulin-1 signals in the heart, whereas ErbB2 and ErbB3 cooperate in neural crest cells.
NRG1B, NRG-1beta, Neuregulin 1, MSTP131, HGL, Glial Growth Factor, GGF1, Heregulin, Alpha, NDF, Neu Differentiation FactorHRG
≥96% by SDS-PAGE and HPLC
Endotoxin Level:
<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.
Biological Activity:
The ED50 was determined by the dose-dependent proliferation of human MCF-7 cells was found to be <0.3ng/ml, corresponding to a specific activity of 2x 106 Units/mg.
Lyophilized from a 0.2 µm filtered 10 mM phosphate buffer, pH 7.0, containing 2% mannitol, 0.5% HSA.
lyophilized protein
Reconstitute at 0.1-1.0 mg/ml in distilled water. This solution can then be diluted into other buffers. To maximize product collection from vial surface, vortex briefly and then spin down to recollect the liquid.
Storage / Stability:

The lyophilized protein is stable for at least 2 years from date of receipt when stored at -20°C. Upon reconstitution, store in working aliquots at +4°C for up to one month, or at -20°C for up to six months, in the presence of a carrier protein. Avoid repeated freeze/thaw cycles.

1. Circulation, Jul 2009, 120: 310 - 317.
2. J. Neurosci., Jun 2009, 29: 7667 - 7678.
3. Invest. Ophthalmol. Vis. Sci., Apr 2009, 50: 2075.
Avoid freeze/thaw cycles
Amino Acid Sequence:
Scientific Category:
Cytokine/Growth Factors
Product Type:
Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.

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