Mocetinostat

Catalog #

27019

$155 *

Size: 25 mg

Qty

Bulk/Custom

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Description

Mocetinostat selectively inhibits histone deacetylases (HDACs) 1-3 and 11 at submicromolar concentrations. It blocks cancer cell proliferation in vitro and has significant antitumor activity in vivo. Mocetinostat induces hyperacetylation of histones, causes expression of the tumor suppressor protein p21(WAF1/CIP1), and inhibits proliferation of human cancer cells growing in culture.

Product Info

Storage and Usage

Citations

Purity

≥99%

Format

A crystalline solid.

Formula

C₂₃H₂₀N₆O

396.4 Da

Solubility

Soluble in DMSO

CAS Registry #

726169-73-9

References

1. Zhou, N., et al. J. Med. Chem. 51: 4072-4075 (2008).
2. Raeppel, S., et al. Bioorg. Med. Chem. Lett. 19: 644-649 (2009).

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Mocetinostat

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