ML161

Catalog #
27764-1
$175 *
Size: 10 mg
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Description

Allosteric and reversible inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50 = 0.26 µM for the inhibition of platelet P-selectin expression on human platelets).

Synonyms
2-bromo-N-[3-(butanoylamino)phenyl]benzamide
Product Info
Storage and Usage
Citations
Purity

≥97%

Target(s)
PAR-1
Formula
C17H17BrN2O2
MW
361.2 Da
Solubility

Insoluble in H2O; ≥16.4 mg/ml in DMSO; ≥46.9 mg/ml in EtOH with ultrasonic. For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Long-term storage in solution is not recommended. Not stable in diluted solutions.

Biological Activity
ML-161 is an antagonist of the protease-activated receptor 1 (PAR1), that inhibits thrombin and SFLLN-induced platelet activation. ML-161 dose dependently inhibits SFLLN-induced expression of P-selectin with an IC50 of 0.26 µM.
CAS Registry #
423735-93-7
Background
ML-161 is thought to act allosterically. ML-161 inhibits thrombin-induced platelet activation.
References
Dockendorff, C., et al. 2012. ACS Med. Chem. Lett. 3: 232-237