Metnase (SETMAR), FLAG-tag Recombinant
Catalog #
51018
$440
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Description
Human Metnase (SETMAR, or SET domain and mariner transposase fusion), GenBank Accession No. NM_006515, a.a. 27-684(end), with N-terminal FLAG-tag, MW=76 kDa, expressed in FreeStyle 293-F cells.
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Synonyms
Setmar, Metnase
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Product Data Gallery
10% SDS-PAGE Coomassie Staining
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
Freestyle 293-F cells
Purity
≥32%
Format
Aqueous buffer solution
Formulation
45 mM Tris-HCl, pH 8.0, 124 mM NaCl, 2.4 mM KCl, 3 mM DTT, 90 ?g/ml FLAG peptide, and 10% glyceroll
MW
76 kDa
Amino Acids
27–684(end)
Genbank #
NM_006515
UniProt #
Q53H47
Background
SETMAR or SET domain and mariner transposase fusion gene is a nonhomologous end-joining repair protein that regulates genomic integration of exogenous DNA by opening chromatin and facilitating joining of DNA ends. SETMAR has histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3. SETMAR also has DNA nicking activity and may play a role in DNA repair. Human Pso4 forms a stable complex with SETMAR that regulates Metnase function in DNA repair. SETMAR has sequence-specific DNA-binding activity and recognizes the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element.
References
1. Wray J. et al., Blood 114(9), 1852-1858 (2009).
2. Williamson E.A. et al., Nucleic Acids Res. 36 (18), 5822-5831 (2008).
2. Williamson E.A. et al., Nucleic Acids Res. 36 (18), 5822-5831 (2008).
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