400 µM S-Adenosylmethionine
Catalog #
52120
$205
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Description
S-(5’-Adenosyl)-L-methionine solution. Useful as a methionine donor in methyltransferase assays.
This product has been cited 2 times.
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Synonyms
S-Adenosylmethionine, AdoMet, SAM, S-Adenosyl-L-methionine, SAMe
Product Info
Storage and Usage
Citations2
Supplied As
400 µM solution in water
Format
Aqueous buffer solution
Formula
C15H22N6O5S
MW
398.4 Da
CAS Registry #
29908-03-0
Background
S-Adenosylmethionine (AdoMet or SAM) plays a pivotal role as a methyl donor in a myriad of biological and biochemical events. It is a cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury.
References
1. Chiang, P.K., et al. FASEB J. 1996 Mar;10(4):471-80.
2. Lu SC, Mato JM. Physiol Rev. 2012 Oct;92(4):1515-42.
3. Finkelstein JD. Clin Chem Lab Med. 2007;45(12):1694-9.
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