Chaetocin

Catalog #

27221

$235 *

Size: 1 mg

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Description

Chaetocin is an inhibitor of histone methyltransferases (HMTs) including SUV39H1 and Lys9-specific HMTs such as G9a. It also has some inhibitory effects on SET7, EZH2, and SET7/9. Chaetocin can also induce cellular oxidative stress, selectively killing cancer cells and rapidly-proliferating primary cells. It is a fungal myotoxin. The inhibitor is useful in epigenetics and cancer research.

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Product Info

Storage and Usage

Citations

Purity

≥95% by HPLC

Format

A crystalline solid.

Formula

C₃₀H₂₈N₆O₆S₄

696.8 Da

Solubility

Soluble in organic solvents purged with an inert gas and solubility is 25 mg/ml.

Biological Activity

Chaetocin inhibits SUV39H1 with an IC50 = 0.8 µM, G9a with an IC50 = 2.5 µM , and DIM5 with an IC50 = 3 µM .

CAS Registry #

28097-03-2

References

1. Greiner, D., et al., Nat. Chem. Biol. 2005;1(3):143-145.
2. Isham, C.R., et al., Blood 2007;109(6):2579-2588.
3. Tibodeau, J.D., et al., Antioxid. Redox Signal. 2009;11(5):1097-1106.

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