Metabolic Enzymes

 

Metabolic enzymes carry out a variety of cellular functions necessary for survival and homeostasis, including proteolysis and digestion, cellular respiration, energy storage, transcription, and response to the environment. These life-sustaining pathways are vital for growth and maintenance of cellular integrity. Metabolic enzymes encompass a wide range of different protein classes, including carboxylases, dehydrogenases, lipoxygenases, oxidoreductases, kinases, lyases, transferases, and more.

Disregulation of metabolic pathways has been linked to diabetes, obesity, hypertension, osteoporosis, hormonal disorders, cancer, and many other diseases. Given the importance of these essential pathways to cellular integrity and survival, it is not surprising that disregulation of delicate metabolic pathways has been linked to a number of human diseases. Targeting metabolic enzymes is of high interest in drug development programs for metabolic diseases such as diabetes, obesity and cancer. For example, Acetyl-coenzymes A (ACC1 and ACC2) are metabolic enzymes involved in fatty acid metabolism and is are attractive metabolic targets against diabetes and obesity. Phosphoglycerate Dehydrogenase (PHGDH) serves as a marker for aggressive breast cancer and melanoma. Nicotinamide Phosphoribosyltransferase (PBEF) regulates insulin secretion, making it a target for type 2 diabetes and tumor metastasis. ATP Citrate Lyase is required for histone acetylation and is highly upregulated in many cancer cells. HSPs are an ideal type of metabolic enzymes used for the study and effectiveness of cancer vaccines, the discovery of anticancer therapeutics, and the development of infectious disease treatments. Finally, Isocitrate Dehydrogenases (IDH1 & 2) are prominant markers for leukemia and brain tumors.

BPS’s portfolio of metabolic enzymes currently includes over 50 different enzymes and is continuously expanding.  Also, learn more about the Screening and Profiling Services for Metabolic Enzymes.

References:
1.    Hsu, P.P., et al., Cell. 2008. 134(5): 703-707.
2.    Maritim, A.C., et al., J. Biochem. Mol. Toxicol. 2003. 17(1): 24-38.

Metabolic Enzyme Subcategories

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Catalog#SizeProduct NamePrice
72047 384 wells IDO1 Fluorogenic Inhibitor Screening Assay Kit (384)
$1,040
73009 10 ml IDO1 Fluorogenic Reaction Solution
$200
72050 50 reactions IDO1 Inhibitor Mechanism of Action Assay Kit
$725
71272 96 reactions IDO1 Primer Mix-qPCR Assay
$135
79081 50 μg IDO1, His-Avi-Tag, Biotin Labeled
$420
71182

Starting at:

50 µg

IDO1, His-tag
Starting at:
$325
71196 50 μg IDO1, His-tag (Mouse)
$320
60532 2 vials IDO1-HEK293 Recombinant Cell Line (Human)
$8,000
60533 2 vials IDO2 - HEK293 Recombinant Cell Line (Human)
$8,000
62001-2 1000 reactions IDO2 Cellular Activity QuickDetect™ Supplements
$1,040
62001-1 100 reactions IDO2 Cellular Activity QuickDetect™ Supplements
$205
71281 96 reactions IDO2 Primer Mix-qPCR Assay
$135
71194-2 100 µg IDO2, His-tag (Human)
$495
71240 200 µg IDO2, His-tag (Mouse)
$320
79485 20 µg KYNU, His-Tag
$350
79514 100 reactions Kynureninase Inhibitor Screening Assay Kit
$765
71081 100 µg LDHA, His-tag
$340
71078 100 µg LDHB, His-tag
$340
70001 20 μg LTA4H, FLAG-His-tags
$340
60502 10 µg Lysyl Oxidase-like 2 (LOXL2), FLAG-tag (Sf9-derived)
$475
60512 10 µg Lysyl Oxidase-like 2 (LOXL2), His-tag (HEK293-derived)
$475
60524 20 µg Lysyl oxidase-like 4 (LOXL4), His-tag (E. coli-derived)
$475
71103 20 µg MAOA, His-tag, FLAG-tag
$465
71402 384 reactions MAT2A Inhibitor Screening Assay Kit
$1,075
79308 50 μg MAT2A, His-Avi-Tag, Biotin-Labeled
$330

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