Metabolic Enzymes

 

Metabolic enzymes carry out a variety of cellular functions necessary for survival and homeostasis, including proteolysis and digestion, cellular respiration, energy storage, transcription, and response to the environment. These life-sustaining pathways are vital for growth and maintenance of cellular integrity. Metabolic enzymes encompass a wide range of different protein classes, including carboxylases, dehydrogenases, lipoxygenases, oxidoreductases, kinases, lyases, transferases, and more.

Disregulation of metabolic pathways has been linked to diabetes, obesity, hypertension, osteoporosis, hormonal disorders, cancer, and many other diseases. Given the importance of these essential pathways to cellular integrity and survival, it is not surprising that disregulation of delicate metabolic pathways has been linked to a number of human diseases. Targeting metabolic enzymes is of high interest in drug development programs for metabolic diseases such as diabetes, obesity and cancer. For example, Acetyl-coenzymes A (ACC1 and ACC2) are metabolic enzymes involved in fatty acid metabolism and is are attractive metabolic targets against diabetes and obesity. Phosphoglycerate Dehydrogenase (PHGDH) serves as a marker for aggressive breast cancer and melanoma. Nicotinamide Phosphoribosyltransferase (PBEF) regulates insulin secretion, making it a target for type 2 diabetes and tumor metastasis. ATP Citrate Lyase is required for histone acetylation and is highly upregulated in many cancer cells. HSPs are an ideal type of metabolic enzymes used for the study and effectiveness of cancer vaccines, the discovery of anticancer therapeutics, and the development of infectious disease treatments. Finally, Isocitrate Dehydrogenases (IDH1 & 2) are prominant markers for leukemia and brain tumors.

BPS’s portfolio of metabolic enzymes currently includes over 50 different enzymes and is continuously expanding.  Also, learn more about the Screening and Profiling Services for Metabolic Enzymes.

References:
1.    Hsu, P.P., et al., Cell. 2008. 134(5): 703-707.
2.    Maritim, A.C., et al., J. Biochem. Mol. Toxicol. 2003. 17(1): 24-38.

Metabolic Enzyme Subcategories

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Catalog#SizeProduct NamePrice
27749-3 100 mg Ezetimibe
$195
71076 100 μg FDH, P. putida, His-tag
$350
71077 10 µg Fucokinase, FLAG-tag
$490
50275

50 µg
200 µg

Galactokinase, His-tag
Starting at:
$205
50275-2 200 µg Galactokinase, His-tag
$480
79596 96 Reactions GLS1 Inhibitor Screening Assay Kit
$745
71102 20 µg GLS1, His-tag
$480
71242 20 µg GLS2, His-tag
$470
71092 50 µg GPD1, His-tag
$300
71087 100 µg HEXA, FLAG-His-tags
$350
71088 100 µg HEXB, FLAG-His-tags
$350
50260 50 µg Human AHCY, GST-tag
$490
50295 20 µg Human PKM2, His-tag
$480
70002 20 µg IDE, His-tag
$480
71099-1 50 µg IDH1 (R132H), FLAG-tag
$275
71099-2 100 µg IDH1 (R132H), FLAG-tag
$480
79376 96 reactions IDH1(R132H) Assay Kit
$510
71075-2 100 µg IDH1, FLAG-tag
$480
71075-1 50 µg IDH1, FLAG-tag
$275
71100-2 100 µg IDH2 (R140Q), FLAG-tag
$480
71100-1 50 µg IDH2 (R140Q), FLAG-tag
$275
79309 96 reactions IDH2(R140Q) Assay Kit
$535
71074-2 100 µg IDH2, FLAG-tag
$480
71074-1 50 µg IDH2, FLAG-tag
$275
62000-2 1000 reactions IDO1 Cellular Activity QuickDetect™ Supplements
$1,095

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