XL-888

Catalog #

27781-1

$320 *

Size: 10 mg

Qty

Bulk/Custom

Add to Favorites

*US Pricing only. For international pricing, please contact your local distributor.

●

Purchase

●

Description

XL-888 is a novel and orally-bioavailable inhibitor of heat shock protein 90 (HSP90) that selectively inhibits HSP90α and HSP90β with IC50s of 22 nM and 44 nM respectively. It also exerts considerably weaker inhibition against a range of other diverse kinases with IC50 more than 3600 nM for all. In recent studies, XL-888 has exhibits strong anti-proliferative activities in a panel of tumor cells with values of IC50 ranging from 0.1 nM to 45.5 nM.

●

Synonyms

Xl 888; Xl888; 2-(butan-2-ylamino)-4-N-[(1R,5S)-8-[5-(cyclopropanecarbonyl)pyridin-2-yl]-8-azabicyclo[3.2.1]octan-3-yl]-5-methylbenzene-1,4-dicarboxamide

●

Product Data Gallery

Product Info

Storage and Usage

Citations

Target(s)

HSP90

Formula

C₂₉H₃₇N₅O₃

503.6 Da

Solubility

Soluble in DMSO

CAS Registry #

1149705-71-4

Background

X-ray crystallographic analysis reveals that the XL-888 binds to HSP90 through the formation of H-bonding between the N-(R)-sec-butylanthranilamide moiety of XL-888 and ASP93 of HSP90.

References

1. Paraiso KH, et al. Clin Cancer Res. 2012; 18(9):2502-2514.
2. Bussenius J, et al. Bioorg Med Chem Lett. 2012; 22(17): 5396-5404.

Skip to the end of the images gallery

Skip to the beginning of the images gallery

XL-888

PRODUCTS

SERVICES

RESOURCES

COMPANY