Donepezil HCl
Catalog #
27619-1
$145
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Description
Donepezil Hydrochloride (Donepezil HCL) is a novel, potent and selective inhibitor of acetylcholinesterase (AChE), an enzyme possibly involved in cognitive dysfunction of patients suffering Alzheimer’s disease (AD), with the half maximal inhibition concentration IC50 value of 6.7 nM.
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Synonyms
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one; hydrochloride, AChE inhibitor
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Product Data Gallery
Product Info
Storage and Usage
Citations
Purity
≥99%
Target(s)
Chromatin/Epigenetics
Formula
C24H30ClNO3
MW
416 Da
Solubility
insoluble in EtOH; insoluble in DMSO; ≥10.4 mg/mL in H2O. For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while.
CAS Registry #
120011-70-3
References
Birks, J., Harvey, R.J . Cochrane Database Syst Rev. 2006 Jan 25;(1):CD001190.