TDO Cell-Based Assay Kit
Catalog #
72033
$565
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Description
The human TDO Cell-Based Assay Kit is designed to monitor the activity of exogenously expressed human TDO in cultured cells.
Purchase of this cell line is for research purposes only; commercial use requires a separate license. View the full terms and conditions.
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Synonyms
Tryptophan 2,3-dioxygenase, TDO2, TDO-2, TDO
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Product Info
Storage and Usage
Citations
Supplied As
The kit contains a transfection-ready expression vector for full length human TDO (hTDO). Upon expression, hTDO can convert L-Trp to Kyn, which gets released and is detected in the assay medium. The kit also includes specialized assay medium.
Format
COMPONENTS:
UniProt #
P48775
Background
L-tryptophan (L-Trp) is an essential amino acid necessary for protein synthesis in mammalian
cells and the L-Trp to kynurenine (Kyn) pathway is firmly established as a key regulator of
innate and adaptive immunity. Catabolism of L-Trp to Kyn maintains an immunosuppressive
microenvironment by starving immune cells of L-Trp and releasing degradation products of L-Trp
that have immunosuppressive functions. Tryptophan 2,3 dioxygenase (TDO), one of the
rate limiting enzymes in this pathway, is upregulated in many tumors, providing cancer cells with
an avenue for immune evasion.
References
1. Yue, E., et al., J. Med. Chem. 2009; 52: 7364–7367.
2. Liu, X., et al., Blood. 2010; 115(17): 3520-3530.
2. Liu, X., et al., Blood. 2010; 115(17): 3520-3530.
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