Rat MET, GST-tag Recombinant

Catalog #

40228

$410 *

Size: 10 µg

Qty

Bulk/Custom

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Description

Recombinant rat MET (a.a. 958-end), with N-terminal GST-tag, expressed by Sf9 insect cells via a baculovirus expression system.

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Synonyms

HGFR

Product Info

Storage and Usage

Citations

Species

Rat

Host Species/Expression System

Sf9 insect cells

Purity

≥75%

Format

Aqueous buffer solution

Formulation

50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.

74 kDa

Amino Acids

958–end

Genbank #

X96786

Tag(s)

N-terminal GST-tag

Background

MET is a proto-oncogene that encodes a transmembrane growth factor receptor which is a heterodimer of two disulphide linked chains of 50 kd (alpha) and 145 kd (beta). MET is widely expressed in the kidney, brain, lung, skin, and embryonic tissue (1). Hepatocyte growth factor (HGF) binds to MET and activates its tyrosine kinase activity. MET is overexpressed and activated in a variety of human cancers including pancreatic, colon, gastric, cervical and ovarian cancers and has been shown to be involved in tumor cell migration and invasion (2).

References

1. Giordano, S. et al: Biosynthesis of the protein encoded by the c-met proto-oncogene. Oncogene. 1989 Nov;4(11):1383-8.
2. Iyer, A. et al: Structure, tissue-specific expression, and transforming activity of the mouse met protooncogene. Cell Growth Differ. 1990 Feb;1(2):87-95.

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Rat MET, GST-tag Recombinant

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