MEK1, GST-tag Recombinant
Catalog #
40123
$410
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Description
Recombinant human MEK1 (mitogen-activated protein kinase, kinase 1), full length. This construct contains an N-terminal GST tag. The recombinant protein was affinity purified and is kinase active.
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Synonyms
MAP2K1; MKK1; MAPKK1; PRKMK1
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Product Info
Storage and Usage
Citations
Species
Human
Construct
MEK1 (GST-Full length)
Host Species/Expression System
Sf9 insect cells
Purity
≥85%
Format
Aqueous buffer solution
Formulation
50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM Glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
MW
72 kDa
Amino Acids
full length
Genbank #
NM_002755
UniProt #
Q02750
Background
MEK1 is a member of the dual specificity protein kinase family that acts as a mitogen-activated protein kinase (MAPK) kinase. MEK1 lies upstream of MAPK/ERK and stimulates the enzymatic activity of MAPK/ERK upon a wide variety of extra- and intracellular signals. As an essential component of MAPK/ERK signal transduction pathway, MEK1 is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development (1). Constitutive activation of MEK1 results in cellular transformation. Thus, MEK1 represents a likely target for pharmacologic intervention in proliferative disease such as cancer (2).
References
1. Sebolt-Leopold., J.S., et al. Nature Med. 5:810-816 (1999).
2. Seger, R., et al. FASEB J. 9:726-735 (1995).
2. Seger, R., et al. FASEB J. 9:726-735 (1995).