M344

Catalog #

27203

$130 *

Size: 5 mg

Qty

Bulk/Custom

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Description

M344 is a histone deacetylase (HDAC) inhibitor also known as D237 or MS 344. It inhibits human HDACs, and shows a three-fold selectivity for inhibition of HDAC6 over HDAC1. M344 has been found to increase the sensitivity of human squamous carcinoma cells to radiation. It has also been found to promote cell cycle arrest and apoptosis in human ovarian cancer cells and endometrial cancer. M344 can also inhibit maize HDAC.

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Synonyms

M344, D237, MS 344

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Product Data Gallery

Product Info

Storage and Usage

Citations

Purity

≥98% by HPLC.

Format

A crystalline solid

Formula

C₁₆H₂₅N₃O₃

307.4 Da

Solubility

Soluble in ethanol is ~3 mg/ml and ~25 mg/ml in DMSO and DMF. For biological experiments, dilute the organic solvent into aqueous buffers or isotonic saline.

Biological Activity

M344 inhibits human HDAC6 with an IC50 of ~14 nM and HDAC1 at ~46 nM.

CAS Registry #

251456-60-7

References

1. Jung, M., et al., J. Med. Chem. 1999; 42: 4669-4679.
2. Remiszewski, S., et al., J. Med. Chem. 2002; 45(4): 753-757.
3. Heltweg, B., et al., J. Med. Chem. 2004.; 47: 5235-5243.

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