LDN-57444

Catalog #
27706-1
$180 *
Size: 10 mg
Qty
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Description

LDN-57444 is a cell permeable ubiquitin C-terminal hydrolase (UCH-L1) inhibitor (Ki=0.4 μM). Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis and causes dramatic alterations in synaptic protein distribution and spine morphology in vivo. LDN-57444 is a useful tool to study UCH-L1 in different pathological conditions such as cancer and neurodegeneration.

Synonyms
1H–Indole–2,3–dione, 5–chloro–1–[(2,5–dichlorophenyl)methyl]–, 3–(O–acetyloxime)
Product Info
Storage and Usage
Citations
Purity
≥98% by TLC.
Format
Yellow powder
Formula
C17H11Cl3N2O3
MW
397.6 Da
Solubility
Soluble in DMSO (20 mg/ml)
CAS Registry #
668467-91-2
References
1. Tan, et al Endoplasmic reticulum stress contributes to the cell death induced by UCH-L1 inhibitor. Mol.Cell.Biochem. 318:109 (2008).
2. Susor, A., et al., Proteomic analysis of porcine oocytes during in vitro maturation reveals essential role for the ubiquitin C-terminal hydrolase-L1. Reprod. 134:559 - 568, (2007) .