LATS1, GST-Tag Recombinant
Recombinant human LATS1 (large tumor suppressor kinase 1), encompassing amino acids 589-end. This construct contains an N terminal GST-Tag. The protein was affiity purified.
LATS1 (large tumor suppressor kinase 1) is a putative serine/threonine kinase. It localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 (cyclin-dependent kinase 2) kinase in early mitosis, which is phosphorylated in a cell-cycle dependent manner. The N-terminal region of the protein is involved in binding CDC2, forming a complex with reduced H1 histone kinase activity, and the C-terminal kinase domain binds to its own N-terminal region, suggesting a potential negative regulation mechanism. LATS1 act as a tumor suppressor, being the core component of the Hippo pathway, and plays an important role in the development of soft-tissue sarcomas, ovarian stromal cell tumors and high sensitivity to cancer treatments. It also seems to participate in restricting autophagy in hepatocellular carcinoma cells treated with sorafenib, decreasing the potency of this therapeutic strategy. A deeper understanding of LATS1 mode of action in healthy and diseased cells will allow for refinement of cancer therapies.
2. St. John. et.al: Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction. Nature Genet. 21: 182-186, 1999.
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