L3MBTL1, GST-tag Recombinant

Catalog #

55000

$460 *

Size: 100 µg

Qty

Bulk/Custom

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Description

Human lethal(3)malignant brain tumor-like protein 1 (L3MBTL1), GenBank Accession No. NM_015478, a.a. 191-530 with N-terminal GST-tag, MW = 65.5 kDa, expressed in an E. coli cell expression system.

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Synonyms

L3MBTL1, H-I(3)mbt, L(3)mbt-like, L(3)mbt protein homolog, Lethal(3) malignant brain tumor-like protein 1

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Product Data Gallery

10% SDS-PAGE Coomassie Staining

L3MBTL1 inhibition curve using a TR-FRET assay (#55200). Representative data only; data may vary by lot.

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

E. coli

Purity

≥88%

Format

Aqueous buffer solution

Formulation

40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 1 mM DTT, 20 mM glutathione, and 20% glycerol

65.5 kDa

Amino Acids

191–530

Genbank #

NM_015478

UniProt #

Q9Y468

Tag(s)

N-terminal GST-tag

Background

Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyl-lysine residues on target proteins, therey acting as a reader of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E atLys26 (H1bK26me1 and H1bK26me2) and histone H4 at Lys-20 (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at Lys-382, leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at Lys-860. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.

References

1. Koga, H., et al., Oncogene. 1999 Jul 1;18(26):3799-809.
2. Trojer, P., et al., Cell. 2007 Jun 1;129(5):915-28.
3. Min, J., et al. Nat. Structl. & Mol. Biol. 2007;14:1229 – 1230.

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Datasheets/Protocols

55000_Lot120925.pdf 55000_Lot121011-G.pdf

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L3MBTL1, GST-tag Recombinant

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