Kinase(s)

 

Protein phosphorylation is a key aspect in the regulation of a large number of cellular processes including cellular division, metabolism, signal transduction, and many more. There are over 500 kinases encoded by the human genome and it has been estimated that kinases regulate approximately 50% of cellular functions. Kinase is the name given to an enzyme that catalyzes the transfer of a phosphate group from ATP to another molecule. Kinases can be broadly separated by their substrate into protein and lipid kinases with the protein kinases being further classified based on their cellular location and the specific amino acid(s) they phosphorylate; cytoplasmic threonine, receptor tyrosine kinases (RTKs), and serine/threonine.

The prominent roles that kinases play in cell division have made them attractive targets for both immunosuppressant drugs and cancer therapeutics. Kinases are highly druggable, and account for over 25% of targets screened by the pharmaceutical industry. Currently, there are over 25 kinase inhibitors that have been approved for clinical use by the FDA, including rapamycin, which was discovered in the 1960s. It was not until three decades later, however, that the target of rapamycin was discovered to be a serine/threonine kinase that was named mammalian target of rapamycin (mTOR). Today rapamycin is approved as an immunosuppressant and a number of mTOR inhibitors are being investigated as treatments for various forms of cancer.

BPS offers a wide selection of kinases, kinase substrates and kinase inhibitors. Our kinases are validated through rigorous QC testing and are suitable for use in nearly all in vitro kinase assays. We also offer kinase inhibitor screening services.

References:

1.   Cohen, P. Nat. Rev. Drug Disc. 2002; 1: 309-315.
2.   Ballou, L.M., et al., J. Chem. Biol. 2008 1(1-4): 27-36.
3.   Loewith, R., et al., Genetics. 2011; 189(4): 1177-1201.

 

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Catalog#SizeProduct NamePrice
27615-2 5 mg CHIR-99021 (CT99021) HCl
$255
40039 10 µg CHK1, GST-tag
$370
40040 10 µg CHK2, His-tag
$345
79346 10 μg CK1 alpha, GST-Tag
$345
79347 10 μg CK1 delta, GST-Tag
$345
79349 10 μg CK1 epsilon, GST-Tag
$345
79348 10 μg CK1 gamma, GST-Tag
$345
40252 10 µg cKit (D816V), His-tag
$345
40253 10 µg cKit (V560G), His-tag
$345
40251 10 µg cKit (V654A), His-tag
$345
40250 10 µg cKit, His-tag
$345
40255 10 µg cMet, GST-tag
$345
40525 200 µg Cofilin 1, GST-tag
$395
40008 10 µg cRAF (RAF1)
$345
79110 10 µg CSF1R, untagged (FMS, CD115)
$345
40410 10 µg CSK, GST-tag
$345
40051 10 µg DAPK1, GST-tag
$345
40049 10 µg DAPK2, GST-tag
$370
40052 10 µg DAPK3, GST-tag
$370
40047 10 µg DCAMKL1, GST-tag
$370
40048 10 µg DCAMKL2, GST-tag
$370
40184 10 µg DDR1, GST-tag
$365
40185 10 µg DDR2, GST-tag
$370
79345 50 μg DLK, GST-Tag
$395
27034 25 mg Doramapimod
$155

Items 101 to 125 of 455 total

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